ea0098c54 | Clinical – Surgery/Applied Pathology | NANETS2023
Ng Moreen
, Sinard John
, Kunstman John
, Kunz Pam
, Misdraji Joseph
Background: Despite the widespread use of immunohistochemistry (IHC), there are debates on how pre-analytic variables influence diagnostic results, including the effect of varying tissue section thickness. Scant literature suggests that tissue thickness can affect stain interpretation, including nuclear stains that rely on assigning tumor cells to the positive category, such as Ki-67, and raise the question of whether tissue section thickness should be standardized for some di...